High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.
Clin Pharmacokinet
; 62(12): 1695-1699, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37819504
ABSTRACT
Isavuconazole exposure-response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42-5.30%) in patients. This highly variable protein binding asks for re-evaluation of current pharmacokinetic and pharmacodynamic targets for isavuconazole.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Nitrilas
Limite:
Humans
Idioma:
En
Revista:
Clin Pharmacokinet
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Holanda