Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.
Regen Med
; 19(4): 189-203, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37855207
ABSTRACT
Aim:
Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials &methods:
A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out.Results:
It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different.Conclusion:
There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
Problema de saúde:
1_geracao_evidencia_conhecimento
Assunto principal:
Traumatismos dos Nervos Periféricos
Tipo de estudo:
Systematic_reviews
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Regen Med
Ano de publicação:
2024
Tipo de documento:
Article