Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model.

Fisher, Jeffrey; Housand, Conrad; Mattie, David; Nong, Andy; Moreau, Marjory; Gilbert, Mary

Fisher, Jeffrey; Housand, Conrad; Mattie, David; Nong, Andy; Moreau, Marjory; Gilbert, Mary.

Afiliação

Fisher J; ScitoVation LLC, RTP, NC, United States of America. Electronic address: jfisher@scitovation.com.
Housand C; Magnolia Sciences, Winter Springs, FL, United States of America.
Mattie D; AFRL/711 HPW/RHBAF, WPAFB, OH, United States of America.
Nong A; ScitoVation LLC, RTP, NC, United States of America.
Moreau M; ScitoVation LLC, RTP, NC, United States of America.
Gilbert M; Office of Research and Development, Center for Public Health and Environmental Assessment, US EPA, RTP, NC, United States of America.

Toxicol Appl Pharmacol ; 479: 116733, 2023 11 15.

Article em En | MEDLINE | ID: mdl-37866708

Assuntos

Água Potável; Percloratos; Gravidez; Feminino; Ratos; Animais; Percloratos/toxicidade; Ratos Sprague-Dawley; Ratos Long-Evans; Hormônios Tireóideos; Tiroxina/metabolismo; Tireotropina

Palavras-chave

HPT axis Model; NAMs; PBPK; Perchlorate; TSH; Thyroid Hormones

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Água Potável / Percloratos Limite: Animals / Pregnancy Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2023 Tipo de documento: Article

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