Effect of Obesity on Mortality in Pulmonary Hypertension-A Systematic Review and Meta-Analysis.
J Cardiovasc Dev Dis
; 10(10)2023 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-37887866
ABSTRACT
Obesity is reported to have a protective effect on mortality in pulmonary hypertension (PH), a phenomenon known as obesity paradox. However, the data are conflicting, with some studies showing decreased mortality while other studies found no effect of obesity on mortality. Therefore, we performed a systematic review and meta-analysis to examine whether there is an association between obesity and mortality in PH. Only patients with PH diagnosed by right heart catheterization were included. We also performed a sub-group analysis of subjects with pre-capillary PH only. A total of six studies met the inclusion criteria, with a sample size of 13,987 patients. Obese subjects had lower mortality compared to non-obese subjects in the combined pre- and post-capillary PH group (hazard ratio 0.79, 95% CI 0.66-0.95, p = 0.01). While obesity was associated with reduction in mortality in the pre-capillary PH group (hazard ratio 0.77, 95% CI 0.60 to 0.98, p = 0.03), this was not uniform across all studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_cardiovascular_diseases
/
6_endocrine_disorders
/
6_obesity
/
6_other_respiratory_diseases
Tipo de estudo:
Systematic_reviews
Idioma:
En
Revista:
J Cardiovasc Dev Dis
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos