Vaccines for HPV-associated diseases.
Mol Aspects Med
; 94: 101224, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37931422
Human papillomavirus (HPV) infection represents a significant global health concern owing to its role in the etiology of conditions ranging from benign low-grade lesions to cancers of the cervix, head and neck, anus, vagina, vulva, and penis. Prophylactic vaccination programs, primarily targeting adolescent girls, have achieved dramatic reductions in rates of HPV infection and cervical cancer in recent years. However, there is a clear demand for a strategy to manage the needs of the many people who are already living with persistent HPV infection and/or HPV-associated conditions. Unlike prophylactic vaccines, which act to prevent HPV infection, therapeutic vaccination presents an opportunity to induce cellular immunity against established HPV infections and lesions and prevent progression to cancer. Several HPV vaccines are undergoing clinical development, using a range of platforms. Peptide- or protein-based vaccines, vector-based vaccines, whole-cell vaccines, and nucleic acid vaccines each offer relative merits and limitations for the delivery of HPV antigens and the subsequent generation of targeted immune responses. There has been particular interest in DNA-based vaccines, which elicit both cellular and humoral immune responses to provide long-lasting immunity. DNA vaccines offer several practical advantages over other vaccine platforms, including the potential for rapid and scalable manufacturing, targeting of many different antigens, and potential for repeat boosting. Furthermore, unlike vectored approaches, DNA vaccines are thermostable over extended time periods, which may enable shipping and storage. Several delivery strategies are available to address the main challenge of DNA vaccines, namely their relatively low transfection efficiency. We review the latest clinical data supporting the development of DNA vaccines and reflect on this exciting prospect in the management of HPV-related disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
10_ODS3_salud_sexual_reprodutiva
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1_ASSA2030
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2_ODS3
Problema de saúde:
10_sexually_transmitted_infections
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1_doencas_nao_transmissiveis
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2_cobertura_universal
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2_enfermedades_transmissibles
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2_muertes_prematuras_enfermedades_notrasmisibles
Assunto principal:
Neoplasias do Colo do Útero
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Vacinas de DNA
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Infecções por Papillomavirus
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Vacinas contra Papillomavirus
Limite:
Adolescent
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Female
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Humans
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Male
Idioma:
En
Revista:
Mol Aspects Med
Ano de publicação:
2023
Tipo de documento:
Article