NGLY1: A fascinating, multifunctional molecule.

Suzuki, Tadashi; Fujihira, Haruhiko

Suzuki, Tadashi; Fujihira, Haruhiko.

Afiliação

Suzuki T; Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research (CPR), RIKEN, Saitama, Japan; Takeda-CiRA Joint Program (T-CiRA), Kanagawa, Japan. Electronic address: tsuzuki_gm@riken.jp.
Fujihira H; Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research (CPR), RIKEN, Saitama, Japan.

Biochim Biophys Acta Gen Subj ; 1868(2): 130379, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37951368

ABSTRACT

ABSTRACT

NGLY1, a cytoplasmic de-N-glycosylating enzyme is well conserved among eukaryotes. This enzyme has attracted considerable attention after mutations on the NGLY1 gene were found to cause a rare genetic disorder called NGLY1 deficiency. Recent explosive progress in NGLY1 research has revealed multi-functional aspects of this protein.

Assuntos

Citoplasma; Citosol; Mutação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citoplasma Idioma: En Revista: Biochim Biophys Acta Gen Subj Ano de publicação: 2024 Tipo de documento: Article

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