Capecitabine-based chemotherapy in early-stage triple-negative breast cancer: a meta-analysis.
Front Oncol
; 13: 1245650, 2023.
Article
em En
| MEDLINE
| ID: mdl-37954087
ABSTRACT
Introduction:
The efficacy and safety of adjuvant capecitabine in early-stage triple-negative breast cancer remains undefined. A meta-analysis was conducted to elucidate whether capecitabine-based regimens could improve survival in early-stage triple-negative breast cancer (TNBC).Methods:
The current study searched Medline, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov proceedings up to 2023.9. Disease-free survival (DFS), overall survival (OS), and grade 3-4 adverse events (AEs) were assessed. Extracted or calculated hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled.Results:
The capecitabine-based regimens showed significant advantages in DFS (HR = 0.81, 95% CI 0.73-0.90; P <.001) and OS (HR = 0.75, 95% CI 0.65-0.87; P <.001) from 12 randomized controlled trials (RCTs) with 5,390 unselected participants. Subgroup analysis of DFS showed analogous results derived from patients with lymph node negative (HR = 0.68, 95% CI 0.50-0.92; P = .006) and capecitabine duration no less than six cycles (HR = 0.73; 95% CI 0.62-0.86; P <.001). Improvement of DFS in the addition group (HR = 0.77, 95% CI 0.68-0.87; P <.001) and adjuvant setting (HR = 0.79, 95% CI 0.70-0.89; P <.001) was observed. As to safety profile, capecitabine was associated with more frequent stomatitis (OR = 5.05, 95% CI 1.45-17.65, P = .011), diarrhea (OR = 6.11, 95% CI 2.12-17.56; P =.001), and hand-foot syndrome (OR = 31.82, 95% CI 3.23-313.65, P = .003).Conclusions:
Adjuvant capecitabine-based chemotherapy provided superior DFS and OS to early-stage TNBC. The benefits to DFS in selected patients with lymph node negative and the addition and extended duration of capecitabine were demonstrated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_diarrhea
Tipo de estudo:
Systematic_reviews
Idioma:
En
Revista:
Front Oncol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China