Efficacy and safety of leuprorelin 3-month depot (11.25â¯mg) for idiopathic central precocious puberty treatment of Chinese girls: a single-center retrospective study.
J Pediatr Endocrinol Metab
; 37(1): 15-20, 2024 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-37975727
ABSTRACT
OBJECTIVES:
This study aimed to evaluate the efficacy and safety of 3-month leuprorelin acetate (3-month LA, 11.25â¯mg) for the treatment of idiopathic central precocious puberty (ICPP) in Chinese girls.METHODS:
We conducted a single-center retrospective study in China on 28 girls with ICPP who received at least one year of 3-month LA treatment. Data from anthropometry, biochemistry, bone age (BA), and pelvic ultrasonography were assessed before and every 6 months during medication.RESULTS:
At CPP diagnosis, the mean chronological age (CA) was 7.8±0.8 years, with bone age advancement (BA-CA) of 1.5±0.8 years. After treatment initiation, growth velocity decreased significantly from 8.5±1.6â¯cm/year to 5.8±1.1â¯cm/year at month 12 (p<0.001). GnRH-stimulated peak LH ≤3IU/L, the primary efficacy criterion, was observed in 27 out of 28 (96.4â¯%) children at month 3. Basal estradiol <20â¯pg/mL was achieved by all 28 girls (100â¯%) at month 6 and remained stable at month 12. Basal follicle-stimulating hormone (FSH) decreased from 4.1±3.5 to 1.7±0.9 (p<0.001), and basal LH was also significantly reduced from 3.3±6.5 to 0.7±0.8 (p=0.035) at month 12. The mean predicted adult height (PAH) at treatment initiation was 152.7±5.8â¯cm, it increased significantly to 157.5±5.5â¯cm (p=0.007) after one-year treatment. Pubertal development was slowed in most patients, and in some cases, it was even reversed. Only one patient (3.6â¯%) reported local intolerance.CONCLUSIONS:
Three-month leuprorelin acetate is a safe and effective treatment for suppressing the pituitary-gonadal axis and restoring impaired adult height in Chinese girls.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
Leuprolida
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China