Investigating the origin of the <sup>13</sup> C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-<sup>13</sup> C]pyruvate injection.

Zhu, Minjie; Jhajharia, Aditya; Josan, Sonal; Park, Jae Mo; Yen, Yi-Fen; Pfefferbaum, Adolf; Hurd, Ralph E; Spielman, Daniel M; Mayer, Dirk

Investigating the origin of the ¹³ C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-¹³ C]pyruvate injection.

Zhu, Minjie; Jhajharia, Aditya; Josan, Sonal; Park, Jae Mo; Yen, Yi-Fen; Pfefferbaum, Adolf; Hurd, Ralph E; Spielman, Daniel M; Mayer, Dirk.

Afiliação

Zhu M; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jhajharia A; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Josan S; Digital Health, Siemens Healthineers, Erlangen, Germany.
Park JM; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yen YF; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Pfefferbaum A; Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Hurd RE; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.
Spielman DM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Mayer D; Department of Radiology, Stanford University School of Medicine, Stanford, California, USA.

NMR Biomed ; 37(3): e5073, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37990800

Assuntos

Ácido Láctico; Ácido Pirúvico; Ratos; Animais; Ácido Pirúvico/metabolismo; Ácido Láctico/metabolismo; Imageamento por Ressonância Magnética/métodos; Encéfalo/diagnóstico por imagem; Encéfalo/metabolismo; Barreira Hematoencefálica/diagnóstico por imagem; Isótopos de Carbono/metabolismo

Palavras-chave

blood-brain barrier; brain metabolism; hyperpolarized 13C; lactate; pyruvate; rat

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Láctico / Ácido Pirúvico Limite: Animals Idioma: En Revista: NMR Biomed Assunto da revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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