Photochemical reductive deamination of alpha-amino aryl alkyl ketones.

Liang, Ji-Yuan; Su, Yi-Wen; Zou, You-Quan

Liang, Ji-Yuan; Su, Yi-Wen; Zou, You-Quan.

Afiliação

Liang JY; Department of Otolaryngology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China. youquanzou@whu.edu.cn.
Su YW; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, Hubei 430071, China.
Zou YQ; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

Chem Commun (Camb) ; 59(99): 14685-14688, 2023 Dec 12.

Article em En | MEDLINE | ID: mdl-37997158

ABSTRACT

ABSTRACT

Photochemical reductive deamination of alpha-amino aryl alkyl ketones under photosensitizer-free conditions is presented. This protocol features high efficiency and selectivity. A plausible reaction pathway is proposed based on ultraviolet-visible absorption investigation, control experiments and deuterium-labelling studies. Mechanistic study reveals that the alpha-hydrogen atom of the ketone product originated from water.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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