Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.

Yang, Zhenle; Ning, Ruofei; Liu, Qianying; Zang, Ruixian; Liu, Suwen; Sun, Shuzhen

Yang, Zhenle; Ning, Ruofei; Liu, Qianying; Zang, Ruixian; Liu, Suwen; Sun, Shuzhen.

Afiliação

Yang Z; Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Ning R; Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Liu Q; Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Zang R; Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Liu S; Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Sun S; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Physiol Rep ; 11(23): e15879, 2023 Dec.

Article em En | MEDLINE | ID: mdl-38030388

Assuntos

Injúria Renal Aguda; Cisplatino; Camundongos; Animais; Humanos; Cisplatino/toxicidade; Fator 2 Relacionado a NF-E2/metabolismo; Antioxidantes/farmacologia; Antioxidantes/uso terapêutico; Antioxidantes/metabolismo; Camundongos Endogâmicos C57BL; Injúria Renal Aguda/induzido quimicamente; Injúria Renal Aguda/tratamento farmacológico; Injúria Renal Aguda/prevenção & controle; Rim/metabolismo; Estresse Oxidativo; Inflamação/metabolismo; Apoptose; Umbeliferonas/farmacologia; Umbeliferonas/uso terapêutico; Umbeliferonas/metabolismo

Palavras-chave

NRF2; UMB; cisplatin-induced AKI; inflammation; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 1_doencas_nao_transmissiveis / 6_kidney_renal_pelvis_ureter_cancer Assunto principal: Cisplatino / Injúria Renal Aguda Limite: Animals / Humans Idioma: En Revista: Physiol Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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