A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis.

Zhang, Yizhuo; Li, Shiyu; Chu, Hongkun; Li, Jing; Lu, Shaohong; Zheng, Bin

Zhang, Yizhuo; Li, Shiyu; Chu, Hongkun; Li, Jing; Lu, Shaohong; Zheng, Bin.

Afiliação

Zhang Y; Laboratory of Pathogen Biology, School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China.
Li S; School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China.
Chu H; Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College , Hangzhou, China.
Li J; Laboratory of Pathogen Biology, School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China.
Lu S; School of Basic Medicine and Forensics, Hangzhou Medical College , Hangzhou, China.
Zheng B; Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College , Hangzhou, China.

Microbiol Spectr ; 12(1): e0286623, 2024 Jan 11.

Article em En | MEDLINE | ID: mdl-38038457

Assuntos

Toxoplasma; Toxoplasmose; Vacinas de DNA; Humanos; Camundongos; Animais; Ovinos; Vacinas de mRNA; Camundongos Endogâmicos BALB C; Proteínas de Protozoários/genética; Imunidade Celular; Toxoplasmose/prevenção & controle; Toxoplasma/genética; Vacinas de DNA/genética; Antígenos de Protozoários

Palavras-chave

Toxoplasma gondii; immune response; lipid nanoparticle; mRNA; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND Problema de saúde: 1_doencas_transmissiveis / 2_enfermedades_transmissibles / 3_neglected_diseases / 3_zoonosis Assunto principal: Toxoplasma / Toxoplasmose / Vacinas de DNA Limite: Animals / Humans Idioma: En Revista: Microbiol Spectr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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