Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis.

Xu, Rongjian; Liu, Xuewen; Zhang, Yufeng; Wang, Kelei; Chen, Zhuolin; Zheng, Jiewen; Zhang, Tan; Tong, Peijian; Qian, Yu; Yang, Wanlei

Xu, Rongjian; Liu, Xuewen; Zhang, Yufeng; Wang, Kelei; Chen, Zhuolin; Zheng, Jiewen; Zhang, Tan; Tong, Peijian; Qian, Yu; Yang, Wanlei.

Afiliação

Xu R; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Liu X; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Zhang Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Wang K; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Chen Z; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Zheng J; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Zhang T; Department of Orthopedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province 312000, China.
Tong P; Department of Orthopedics Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, China. Electronic address: peijiantong@zcmu.edu.cn.
Qian Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Department of Orthopedics Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou,
Yang W; Department of Orthopedics Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, China. Electronic address: 20223010@zcmu.edu.cn.

Biochem Pharmacol ; 219: 115964, 2024 01.

Article em En | MEDLINE | ID: mdl-38049011

Assuntos

Reabsorção Óssea; Osteoporose; Animais; Camundongos; Feminino; Humanos; Osteogênese; NF-kappa B/metabolismo; Reabsorção Óssea/prevenção & controle; Osteoclastos; Osteoporose/tratamento farmacológico; Osteoporose/prevenção & controle; Ligante RANK/farmacologia; Ovariectomia; Diferenciação Celular; Histona-Lisina N-Metiltransferase

Palavras-chave

(R)-PFI-2; NF-κB; Osteoclastogenesis; Osteoporosis; Transcriptional coactivator with PDZ-binding motif (TAZ)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Reabsorção Óssea Limite: Animals / Female / Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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