Growth and developmental outcomes of infants with hypoxic ischemic encephalopathy.
Sci Rep
; 13(1): 23100, 2023 12 28.
Article
em En
| MEDLINE
| ID: mdl-38155236
ABSTRACT
Despite advances in obstetric care, hypoxic ischemic encephalopathy (HIE) remains a significant disease burden. We determined the national trends of HIE prevalence, therapeutic hypothermia (TH) use, mortality, and outcomes from 2012 to 2019. This study included term infants diagnosed with HIE between 2012 and 2019 from the National Health Insurance Service database. The prevalence of HIE was 2.4 per 1000 births without significant change during the period. TH was performed in approximately 6.7% of infants with HIE, and the annual variation ranged from 2.4 to 12.5%. The mortality among all term infants with HIE was 4.6%. The mortality rate among infants with HIE and TH significantly declined from 40 to 16.9% during the eight years. Infants with TH had higher mortality, increased use of inhaled nitric oxide, and more invasive ventilator use, indicating greater disease severity in the TH group. Infants with TH also showed significantly poorer outcomes, including delayed development, cerebral palsy, sensorineural hearing loss, and seizure, compared to infants without TH (p < 0.0001). With the increasing application of TH, mortality and developmental outcomes among infants with HIE have been improving in the past eight years in Korea. Further efforts to improve outcomes should be needed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de saúde:
2_muertes_prevenibles
/
6_cardiovascular_diseases
/
6_cerebrovascular_disease
/
6_epilepsy
/
7_neonatal_care_health
/
7_non_communicable_diseases
/
7_nutrition
Assunto principal:
Paralisia Cerebral
/
Hipóxia-Isquemia Encefálica
/
Hipotermia Induzida
Limite:
Humans
/
Infant
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2023
Tipo de documento:
Article