Etiologies of Mild and Moderate Diarrheal Illness among Children in Consuelo, Dominican Republic.
Am J Trop Med Hyg
; 110(2): 339-345, 2024 02 07.
Article
em En
| MEDLINE
| ID: mdl-38167390
ABSTRACT
Since the rotavirus vaccine was included in the Dominican Republic's national immunization schedule in 2012, the microbiologic etiologies of acute gastroenteritis have not been described. This study aimed to determine the contribution of rotavirus as an etiology of acute gastroenteritis over a 12-month period in children under 5 years of age in both an inpatient and an outpatient setting in Consuelo, Dominican Republic. All children who were seen at Niños Primeros en Salud clinic or admitted to Hospital Municipal Dr. Angel Ponce Pinedo for acute gastroenteritis during January 2021-April 2022 were enrolled in the study. Stools were evaluated for rotavirus, enteric parasites, and pathogenic bacteria. Pathogen detection was compared between outpatients and inpatients and on the basis of child's vaccination status. From 181 children enrolled, 170 stool samples were collected, 28 (16.5%) from inpatients and 142 (83.5%) from outpatients. Rotavirus was the most commonly detected pathogen and was proportionately more common among hospitalized children, with nine (32.1%) cases among hospitalized children and 16 (11.3%) among outpatient children. (Pearson χ2 = 8.1, P = 0.004). Among patients with a positive rotavirus result, vaccination rate was lower among moderate (hospitalized) (three of six; 50%) compared with mild (outpatient) diarrhea patients (12 of 15; 80%). Giardia lamblia (10%) was the next most prevalent pathogen detected in both inpatients and outpatients using standard laboratory measures. Despite the availability of rotavirus vaccination, rotavirus remains a common cause of gastrointestinal illness among children under 5 years of age in our cohort. Incomplete vaccination status was associated with hospitalization for gastrointestinal illness.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
3_ND
Problema de saúde:
1_doencas_transmissiveis
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1_medicamentos_vacinas_tecnologias
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2_enfermedades_transmissibles
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3_diarrhea
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3_neglected_diseases
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3_zoonosis
Assunto principal:
Infecções por Rotavirus
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Rotavirus
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Vacinas contra Rotavirus
/
Gastroenterite
Tipo de estudo:
Etiology_studies
Limite:
Child
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Child, preschool
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Humans
/
Infant
País/Região como assunto:
Caribe ingles
/
Dominica
/
Republica dominicana
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
República Dominicana