Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Biol Pharm Bull
; 47(2): 486-498, 2024 Feb 22.
Article
em En
| MEDLINE
| ID: mdl-38199251
ABSTRACT
Resina Draconis is a traditional Chinese medicine, with the in-depth research, its medicinal value in anti-tumor has been revealed. Loureirin A is extracted from Resina Draconis, however, research on the anti-tumor efficacy of Loureirin A is rare. Herein, we investigated the function of Loureirin A in melanoma. Our research demonstrated that Loureirin A inhibited the proliferation of and caused G0/G1 cell cycle arrest in melanoma cells in a concentration-dependent manner. Further study showed that the melanin content and tyrosinase activity was enhanced after Loureirin A treatment, demonstrated that Loureirin A promoted melanoma cell differentiation, which was accompanied with the reduce of WNT signaling pathway. Meanwhile, we found that Loureirin A suppressed the migration and invasion of melanoma cells through the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. Taken together, this study demonstrated for the first time the anti-tumor effects of Loureirin A in melanoma cells, which provided a novel therapeutic strategy against melanoma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chalconas
/
Proteínas Proto-Oncogênicas c-akt
/
Melanoma
Limite:
Humans
Idioma:
En
Revista:
Biol Pharm Bull
/
Biol. pharm. bull
/
Biological and pharmaceutical bulletin
Assunto da revista:
BIOQUIMICA
/
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article