Generation of the human induced pluripotent stem cell line PUMCi005-A from a patient with Perrault syndrome.
Stem Cell Res
; 75: 103318, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38295749
ABSTRACT
We generated PUMCi005-A, an induced pluripotent stem cell (iPSC) line, from dermal fibroblasts of a 32-year-old female Perrault syndrome patient with double heterozygous (794 G > A and 1181 G > A) mutations in the TWNK gene using Sendai viral delivery of OCT4, SOX2, KLF4, and c-MYC. The PUMCi005-A iPSC line carried the TWNK mutations, displayed typical iPSC morphology, expressed pluripotent stem cell markers, did not have integration of Sendai virus, and exhibited a normal karyotype and differentiation into three germ layers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disgenesia Gonadal 46 XX
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Células-Tronco Pluripotentes Induzidas
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Perda Auditiva Neurossensorial
Limite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Stem Cell Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China