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Dissolvable Immunomodulatory Microneedles for Treatment of Skin Wounds.
Ghelich, Pejman; Samandari, Mohamadmahdi; Hassani Najafabadi, Alireza; Tanguay, Adam; Quint, Jacob; Menon, Nikhil; Ghanbariamin, Delaram; Saeedinejad, Farnoosh; Alipanah, Fatemeh; Chidambaram, Ramaswamy; Krawetz, Roman; Nuutila, Kristo; Toro, Steven; Barnum, Lindsay; Jay, Gregory D; Schmidt, Tannin A; Tamayol, Ali.
Afiliação
  • Ghelich P; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Samandari M; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Hassani Najafabadi A; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Tanguay A; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Quint J; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Menon N; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Ghanbariamin D; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Saeedinejad F; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Alipanah F; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Chidambaram R; Center for Comparative Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Krawetz R; McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, AB, T2N 4Z6, Canada.
  • Nuutila K; Department of Surgery, University of Calgary, Calgary, AB, T2N 1N4, Canada.
  • Toro S; US Army Institute of Surgical Research, Fort Sam Houston, Texas, 78234, USA.
  • Barnum L; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Jay GD; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
  • Schmidt TA; Emergency Medicine, Brown University, Providence, RI, 02908, USA.
  • Tamayol A; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Adv Healthc Mater ; 13(16): e2302836, 2024 06.
Article em En | MEDLINE | ID: mdl-38299437
ABSTRACT
Sustained inflammation can halt or delay wound healing, and macrophages play a central role in wound healing. Inflammatory macrophages are responsible for the removal of pathogens, debris, and neutrophils, while anti-inflammatory macrophages stimulate various regenerative processes. Recombinant human Proteoglycan 4 (rhPRG4) is shown to modulate macrophage polarization and to prevent fibrosis and scarring in ear wound healing. Here, dissolvable microneedle arrays (MNAs) carrying rhPRG4 are engineered for the treatment of skin wounds. The in vitro experiments suggest that rhPRG4 modulates the inflammatory function of bone marrow-derived macrophages. Degradable and detachable microneedles are developed from gelatin methacryloyl (GelMA) attach to a dissolvable gelatin backing. The developed MNAs are able to deliver a high dose of rhPRG4 through the dissolution of the gelatin backing post-injury, while the GelMA microneedles sustain rhPRG4 bioavailability over the course of treatment. In vivo results in a murine model of full-thickness wounds with impaired healing confirm a decrease in inflammatory biomarkers such as TNF-α and IL-6, and an increase in angiogenesis and collagen deposition. Collectively, these results demonstrate rhPRG4-incorporating MNA is a promising platform in skin wound healing applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Gelatina / Agulhas Limite: Animals / Humans Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Gelatina / Agulhas Limite: Animals / Humans Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos