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Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating.
Zhu, Yang; Deng, Kaicheng; Zhou, Jianwei; Lai, Chong; Ma, Zuwei; Zhang, Hua; Pan, Jiazhen; Shen, Liyin; Bucknor, Matthew D; Ozhinsky, Eugene; Kim, Seungil; Chen, Guangjie; Ye, Sang-Ho; Zhang, Yue; Liu, Donghong; Gao, Changyou; Xu, Yonghua; Wang, Huanan; Wagner, William R.
Afiliação
  • Zhu Y; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China. zhuyang@zju.edu.cn.
  • Deng K; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. zhuyang@zju.edu.cn.
  • Zhou J; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. zhuyang@zju.edu.cn.
  • Lai C; Binjiang Institute of Zhejiang University, Hangzhou, China. zhuyang@zju.edu.cn.
  • Ma Z; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhuyang@zju.edu.cn.
  • Zhang H; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
  • Pan J; School of Electromechanical and Energy Engineering, NingboTech University, Ningbo, Zhejiang, China.
  • Shen L; Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • Bucknor MD; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Ozhinsky E; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
  • Kim S; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
  • Chen G; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
  • Ye SH; Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
  • Zhang Y; Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
  • Liu D; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gao C; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Xu Y; Department of Urology, The Children's Hospital, School of Medicine, National Clinical Research Center for Child Health, Zhejiang University, Hangzhou, Zhejiang, China.
  • Wang H; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Wagner WR; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Nat Commun ; 15(1): 1123, 2024 Feb 06.
Article em En | MEDLINE | ID: mdl-38321028
ABSTRACT
Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliuretanos / Ablação por Ultrassom Focalizado de Alta Intensidade Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliuretanos / Ablação por Ultrassom Focalizado de Alta Intensidade Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China