Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer.
Trends Cancer
; 10(4): 289-311, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38350736
ABSTRACT
Cancer metastasis causes over 90% of cancer patient fatalities. Poor prognosis is determined by tumor type, the tumor microenvironment (TME), organ-specific biology, and animal physiology. While model organisms do not fully mimic the complexity of humans, many processes can be studied efficiently owing to the ease of genetic, developmental, and cell biology studies. For decades, Drosophila has been instrumental in identifying basic mechanisms controlling tumor growth and metastasis. The ability to generate clonal populations of distinct genotypes in otherwise wild-type animals makes Drosophila a powerful system to study tumor-host interactions at the local and global scales. This review discusses advancements in tumor biology, highlighting the strength of Drosophila for modeling TMEs and systemic responses in driving tumor progression and metastasis.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Drosophila
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cancer
/
Trends in cancer (Online)
Ano de publicação:
2024
Tipo de documento:
Article