Lung Transplantation in Pulmonary Arterial Hypertension: The Portuguese Experience.
Transplant Proc
; 56(5): 1115-1120, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38423833
ABSTRACT
BACKGROUND:
In patients with pulmonary arterial hypertension (PAH), refractory to medical therapy, lung transplantation emerges as an option. This study describes the outcomes of 8 PAH patients who underwent lung transplantation.METHODS:
A retrospective, single-center study was conducted among patients with PAH who underwent lung transplantation in our center.RESULTS:
Patients had a median age of 46 years, with female sex predominance (75%). Causes of HAP were pulmonary veno-occlusive disease (n = 5, 62.5%), idiopathic PAH (n = 2, 25%), and heritable PAH (n = 1, 12.5%). Pre-transplant hemodynamics revealed a median mean pulmonary artery pressure of 58.5 mm Hg (48-86). All patients received bilateral lung transplants with extracorporeal membrane oxygenation support, displaying immediate post-transplant hemodynamic improvement. Primary graft dysfunction grade 3 (PGD 3) was observed in 75% of patients. Five patients (62.5%) died, with a 72.9% survival at 12 months and 29.2% at 24 months post-transplantation.CONCLUSION:
Our study reveals the complexity and challenges of lung transplants in patients with PAH. Despite notable immediate hemodynamic improvements, high rates of PGD 3 and the survival rate remain a concern. Further research to define optimal peri and post-transplant management to improve survival is required.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Pulmão
/
Hipertensão Arterial Pulmonar
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Transplant Proc
/
Transplant. proc
/
Transplantation proceedings
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Portugal