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Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment.
Szabó, Anna; De Decker, Ignace; Semey, Sam; E Y Claes, Karel; Blondeel, Phillip; Monstrey, Stan; Dorpe, Jo Van; Van Vlierberghe, Sandra.
Afiliação
  • Szabó A; Polymer Chemistry and Biomaterials Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium.
  • De Decker I; Burn Center, Ghent University Hospital, Ghent, Belgium.
  • Semey S; Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium.
  • E Y Claes K; Polymer Chemistry and Biomaterials Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium.
  • Blondeel P; Burn Center, Ghent University Hospital, Ghent, Belgium.
  • Monstrey S; Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium.
  • Dorpe JV; Burn Center, Ghent University Hospital, Ghent, Belgium.
  • Van Vlierberghe S; Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium.
Drug Deliv ; 31(1): 2305818, 2024 Dec.
Article em En | MEDLINE | ID: mdl-38424728
ABSTRACT
Burn injuries can result in a significant inflammatory response, often leading to hypertrophic scarring (HTS). Local drug therapies e.g. corticoid injections are advised to treat HTS, although they are invasive, operator-dependent, extremely painful and do not permit extended drug release. Polymer-based microneedle (MN) arrays can offer a viable alternative to standard care, while allowing for direct, painless dermal drug delivery with tailorable drug release profile. In the current study, we synthesized photo-crosslinkable, acrylate-endcapped urethane-based poly(ε-caprolactone) (AUP-PCL) toward the fabrication of MNs. Physico-chemical characterization (1H-NMR, evaluation of swelling, gel fraction) of the developed polymer was performed and confirmed successful acrylation of PCL-diol. Subsequently, AUP-PCL, and commercially available PCL-based microneedle arrays were fabricated for comparative evaluation of the constructs. Hydrocortisone was chosen as model drug. To enhance the drug release efficiency of the MNs, Brij®35, a nonionic surfactant was exploited. The thermal properties of the MNs were evaluated via differential scanning calorimetry. Compression testing of the arrays confirmed that the MNs stay intact upon applying a load of 7 N, which correlates to the standard dermal insertion force of MNs. The drug release profile of the arrays was evaluated, suggesting that the developed PCL arrays can offer efficient drug delivery for up to two days, while the AUP-PCL arrays can provide a release up to three weeks. Finally, the insertion of MN arrays into skin samples was performed, followed by histological analysis demonstrating the AUP-PCL MNs outperforming the PCL arrays upon providing pyramidical-shaped perforations through the epidermal layer of the skin.
AUP-PCL MN arrays provide long-term transdermal drug delivery of hydrocortisoneAUP-PCL-based MN arrays provide superior drug release profiles compared to PCL MNsEffective skin penetration AUP-PCL-based MNs on skin was achieved.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Cicatriz Hipertrófica Limite: Humans Idioma: En Revista: Drug Deliv Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Cicatriz Hipertrófica Limite: Humans Idioma: En Revista: Drug Deliv Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica
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