Associations of maternal and personal smoking with all-cause and cause-specific mortality risk and life expectancy: a prospective cohort study.
Public Health
; 229: 144-150, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38442596
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate the individual and combined effects of maternal smoking during pregnancy (MSDP) and personal smoking on mortality and life expectancy. STUDYDESIGN:
A prospective cohort study based on the UK Biobank, with a median follow-up of 12.47 years.METHODS:
This study employed multivariate Cox regression to determine the relative risks of mortality from all causes and specific diseases according to maternal and/or personal smoking status and pack-years of smoking (0, 1-20, 21-30, >30). Additionally, this study estimated the additive interaction between the two exposures. Life table analyses were performed using the estimated age-specific mortality rates to forecast life expectancy.RESULTS:
Results indicated that MSDP elevated the risk of all-cause mortality (HR = 1.12, 95% CI 1.09-1.15) and mortality due to neoplasms (HR = 1.10, 95% CI 1.06-1.12), circulatory (HR = 1.13, 95% CI 1.06-1.19), respiratory (HR = 1.27, 95% CI 1.16-1.40) and digestive system diseases (HR = 1.22, 95% CI 1.08-1.38). Notably, both multiplicative and additive interactions were observed between maternal and personal smoking, with Relative Excess Risk due to Interaction (RERI) values for mortality from all causes, neoplasms, circulatory, and respiratory diseases being 0.21, 0.22, 0.16, and 0.76, respectively. This study also found a trend towards shorter gained life expectancy when maternal smoking and increasing pack-years of personal smoking were combined.CONCLUSIONS:
In this cohort study of UK Biobank, MSDP was associated with an increased risk of all-cause mortality and reduced life expectancy, suggesting that quitting smoking during pregnancy might have health and longevity benefits for both generations.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_mortalidade_materna
Assunto principal:
Expectativa de Vida
/
Neoplasias
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Public Health
/
Public health
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China