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Cardiorespiratory effects of indoor ozone exposure during sleep and the influencing factors: A prospective study among adults in China.
Li, Luyi; Zhang, Wenlou; Liu, Shan; Wang, Wanzhou; Ji, Xuezhao; Zhao, Yetong; Shima, Masayuki; Yoda, Yoshiko; Yang, Di; Huang, Jing; Guo, Xinbiao; Deng, Furong.
Afiliação
  • Li L; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Zhang W; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Liu S; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Wang W; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Ji X; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Zhao Y; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Shima M; Department of Public Health, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan.
  • Yoda Y; Department of Public Health, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan.
  • Yang D; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Huang J; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Guo X; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
  • Deng F; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Center for Environment and Health, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: lotus321321@126.com.
Sci Total Environ ; 924: 171561, 2024 May 10.
Article em En | MEDLINE | ID: mdl-38458472
ABSTRACT
Ambient ozone (O3) is recognized as a significant air pollutant with implications for cardiorespiratory health, yet the effects of indoor O3 exposure have received less consideration. Furthermore, while sleep occupies one-third of life, research on the health consequences of O3 exposure during this crucial period is scarce. This study aimed to investigate associations of indoor O3 during sleep with cardiorespiratory function and potential predisposing factors. A prospective study among 81 adults was conducted in Beijing, China. Repeated measurements of cardiorespiratory indices reflecting lung function, airway inflammation, cardiac autonomic function, blood pressure, systemic inflammation, platelet and glucose were performed on each subject. Real-time concentrations of indoor O3 during sleep were monitored. Associations of O3 with cardiorespiratory indices were evaluated using linear mixed-effect model. Effect modification by baseline lifestyles (diet, physical activity, sleep-related factors) and psychological status (stress and depression) were investigated through interaction analysis. The average indoor O3 concentration during sleep was 20.3 µg/m3, which was well below current Chinese indoor air quality standard of 160 µg/m3. O3 was associated with most respiratory indicators of decreased airway function except airway inflammation; whereas the cardiovascular effects were only manifested in autonomic dysfunction and not in others. An interquartile range increases in O3 at 6-h average was associated with changes of -3.60 % (95 % CI -6.19 %, -0.93 %) and -9.60 % (95 % CI -14.53 %, -4.39 %) in FVC and FEF25-75, respectively. Further, stronger effects were noted among participants with specific dietary patterns, poorer sleep and higher level of depression. This study provides the first general population-based evidence that low-level exposure to indoor O3 during sleep has greater effects on the respiratory system than on the cardiovascular system. Our findings identify the respiratory system as an important target for indoor O3 exposure, and particularly highlight the need for greater awareness of indoor air quality, especially during sleep.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Poluentes Atmosféricos / Poluição do Ar Limite: Adult / Humans País/Região como assunto: Asia Idioma: En Revista: Sci Total Environ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Poluentes Atmosféricos / Poluição do Ar Limite: Adult / Humans País/Região como assunto: Asia Idioma: En Revista: Sci Total Environ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
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