Association between Portal Vein Thrombosis after Umbilical Vein Catheterization and Neonatal Asphyxia.
Neonatology
; 121(4): 478-484, 2024.
Article
em En
| MEDLINE
| ID: mdl-38522417
ABSTRACT
INTRODUCTION:
Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterization (UVC), but risk factors remain unclear. This study aims to analyze the variables associated to PVT in near- to full-term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE).METHODS:
This is retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1,500 g. All infants were assessed for UVC location and PVT using ultrasonography performed between day 5 and day 10 after catheterization.RESULTS:
Among 213 eligible patients, PVT was diagnosed in 57 (27%); among them, 54 (95%) were localized in the left portal vein branch. With all significant factors in univariate analysis considered, higher gestational age at birth (adjusted OR 1.35; 95% CI 1.12-1.64, p = 0.002) and duration of UVC placement (adjusted OR 1.36; 95% CI 1.11-1.67, p = 0.004) were the main risk factors of PVT. Among 87 infants who were cooled for HIE, 31 (36%) had PVT compared to 26 (21%) in infants without CTH. Using a multivariate model including variables linked to treatment procedures only, an increased PVT incidence was statistically associated with UVC duration (adjusted OR 1.33; 95% CI 1.08; 1.63, p = 0.01) and CTH (adjusted OR 1.94; 95% CI 1.04-3.65, p = 0.04).CONCLUSION:
Left PVT was frequently observed in near- to full-term neonates with UVC. Among factors linked to treatment procedures, both duration of UVC and CTH exposure for HIE were found to be independent risk factors of PVT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Asfixia Neonatal
/
Veias Umbilicais
/
Idade Gestacional
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Trombose Venosa
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Hipotermia Induzida
Limite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Revista:
Neonatology
Assunto da revista:
PERINATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França