A Meta-Analysis of MiRNA-497 and Prognosis of Hepatocellular Carcinoma.
Can J Gastroenterol Hepatol
; 2024: 2211179, 2024.
Article
em En
| MEDLINE
| ID: mdl-38529202
ABSTRACT
Background:
Recently, microRNA-497 (miR-497) has been reported as a prognostic marker for hepatocellular carcinoma (HCC). However, there is no systematic study summarizing these data. Herein, we elucidated the prognostic role of miR497 in HCC by using meta-analysis.Methods:
We systematically searched Embase, PubMed, Web of Science, and, China National Knowledge Infrastructure for relevant studies. The two researchers conducted data extraction and quality evaluation independently. We used hazard ratios (HRs), odds ratios (ORs), and their 95% confidence interval (95% CI) to evaluate the relationship between miR-497 expression level and HCC prognosis.Results:
A total of 6 studies involving 457 participants were included in this meta-analysis. There was a significant association between the lower level of miR-497 expression and the shorter overall survival (HR = 2.17, 95% CI 1.67-2.84, P < 0.001). Meanwhile, patients with low miR-497 expression were more prone to vascular infiltration (OR = 2.73, 95% 1.79-4.17, P < 0.001). However, the lower expression level of miR-497 had no significant correlation with TNM (tumor-node-metastasis) stage (OR = 1.47, 95% CI 0.17-12.49, P=0.47).Conclusions:
MiR-497 might serve as a prognostic biomarker in HCC, but more clinical studies are needed to confirm this view.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
MicroRNAs
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Revista:
Can J Gastroenterol Hepatol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China