Factors associated with hepatitis A susceptibility among men who have sex with men using HIV pre-exposure prophylaxis in Northeastern Brazil: A cross-sectional study.
PLoS One
; 19(3): e0301397, 2024.
Article
em En
| MEDLINE
| ID: mdl-38547222
ABSTRACT
Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with men (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated with HAV susceptibility among cisgender MSM on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil. From September 30, 2021 to June 19, 2023, 282 cisgender MSM receiving HIV PrEP were enrolled into this cross-sectional study. Sociodemographic and clinical information were collected. Blood samples were collected for screening of sexually transmitted infections (STIs) and serum samples were tested for IgM and total anti-HAV antibodies. Non-reactive results for total anti-HAV antibodies were found in 106 of 282 (37.6%) participants. Factors associated with HAV susceptibility included age <30 years (prevalence ratio [PR] 2.02; 95% confidence interval [95% CI] 1.61-2.53), having health insurance (PR 1.39; 95% CI 1.19-1.64), sex only with cisgender men (PR 1.52; 95% CI 1.23-1.89), non-steady partner (PR 1.20; 95% CI 1.01-1.43) and no lifetime history of STIs (PR 1.25; 95% CI 1.03-1.53). Identifying clinical correlates of HAV susceptibility in key populations is a fundamental step towards development of public policy focused on prevention, especially following the recent hepatitis A outbreak in Brazil.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
4_TD
Problema de saúde:
1_doencas_nao_transmissiveis
/
2_enfermedades_transmissibles
/
4_hepatitis
Assunto principal:
Infecções Sexualmente Transmissíveis
/
Infecções por HIV
/
Vírus da Hepatite A
/
Profilaxia Pré-Exposição
/
Minorias Sexuais e de Gênero
/
Hepatite A
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil