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Thymic NK-Cells and Their Potential in Cancer Immunotherapy.
Forbes, Caitlyn; Nierkens, Stefan; Cornel, Annelisa M.
Afiliação
  • Forbes C; Princess Máxima Center for Pediatric Oncology, Utrecht University, Utrecht, the Netherlands.
  • Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht University, Utrecht, the Netherlands.
  • Cornel AM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Immunotargets Ther ; 13: 183-194, 2024.
Article em En | MEDLINE | ID: mdl-38558927
ABSTRACT
Natural killer (NK)-cells are innate immune cells with potent anti-tumor capacity, capable of recognizing target cells without prior exposure. For this reason, NK-cells are recognized as a useful source of cell therapy. Although most NK-cells are derived from the bone marrow (BM), a separate developmental pathway in the thymus also exists, producing so-called thymic NK-cells. Unlike conventional NK-cells, thymic NK (tNK)-cells have a combined capacity for cytokine production and a natural ability to kill tumor cells in the presence of NK-cell receptor stimulatory ligands. Furthermore, tNK-cells are reported to express CD3 subunits intracellularly, without the presence of a rearranged T-cell receptor (TCR). This unique feature may enable harnessing of these cells with a TCR to combine NK- and T-cell effector properties in one cell type. The development, phenotype, and function of tNK-cells, and potential as a cell therapy is, however, poorly explored. In this review, we provide an overview of current literature on both murine and human tNK-cells in comparison to conventional BM-derived NK-cells, and discuss the potential applications of this cellular subset in the context of cancer immunotherapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Immunotargets Ther Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Immunotargets Ther Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda
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