ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.
APMIS
; 132(7): 515-525, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38566447
ABSTRACT
The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single-nucleotide polymorphisms (SNPs) in ST2 and IL-33 were determined, and associations of the SNP variants with serum levels of sST2 and IL-33 at age of 13 months and with recurrent wheezing and childhood asthma at 7 years of age were analyzed. Children with ST2 rs1041973 AC/AA genotypes had significantly lower level of serum sST2 (2453 pg/mL; IQR 2265) than those with CC genotype (5437 pg/mL; IQR 2575; p = < 0.0001). Similar difference was also observed with ST2 rs13408661. No differences were observed between subjects with studied IL-33 SNPs. Children who carried genetic variants of ST2 rs1041973 or rs13408661 seemed to have a higher risk of asthma. In contrast, children who carried genetic variants of IL-33 rs12551268 were less often diagnosed with asthma. Even though these SNPs seemed to associate with asthma, the differences were not statistically significant.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
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Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
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Interleucina-33
/
Proteína 1 Semelhante a Receptor de Interleucina-1
Limite:
Child
/
Child, preschool
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Female
/
Humans
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Infant
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Male
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
APMIS
/
APMIS acta pathol. microbiol. immunol. scand
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
/
PATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Finlândia