Contamination of dairy products with tris(2,4-di-tert-butylphenyl) phosphite and implications for human exposure.
Food Chem
; 448: 139144, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38579559
ABSTRACT
Tris(2,4-di-tert-butylphenyl) phosphite (AO168), an organophosphite antioxidant, can be oxidized to tris(2,4-di-tert-butylphenyl) phosphate (AO168 = O) during the production, processing, and application of plastics. AO168 = O can be further transformed to bis(2,4-di-tert-butylphenyl) phosphate and 2,4-di-tert-butylphenol. Here, we discovered the contamination of AO168 and its transformation products in dairy products for the first time. More samples contained AO168 (mean concentration 8.78 ng/g wet weight [ww]), bis(2,4-di-tert-butylphenyl) phosphate (mean11.1 ng/g ww) and 2,4-di-tert-butylphenol (mean 46.8 ng/g ww) than AO168 = O (mean 40.2 ng/g ww). The concentrations of AO168 and its transformation products were significantly correlated, and differed with the packaging material and storage conditions of the product. Estimated daily intakes (EDIs) of AO168 and its transformation products were calculated. Although the overall dietary risks were below one, transformation products accounted for 96.7% of the total hazard quotients. The high-exposure EDIs of total AO168 were above the threshold of toxicological concern (300 ng/kg bw/day), and deserve continual monitoring.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contaminação de Alimentos
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Fosfitos
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Laticínios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Food Chem
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Food chem
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Food chemistry
Ano de publicação:
2024
Tipo de documento:
Article