Lymphovascular invasion is associated with poor long-term outcomes in patients with pT1N0-3 or pT2-3N0 remnant gastric cancer: a retrospective cohort study.
World J Surg Oncol
; 22(1): 86, 2024 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-38581014
ABSTRACT
BACKGROUND:
Lymphovascular invasion (LVI) is a poor prognostic factor in various malignancies. However, its prognostic effect in remnant gastric cancer (RGC) remains unclear. We examined the correlation between LVI and disease prognosis in patients with T1N0-3 or T2-3N0 RGC in whom adjuvant chemotherapy was not indicated and a treatment strategy was not established.METHODS:
We retrospectively analyzed patients with T1N0-3 and T2-3N0 RGC who underwent curative surgery at the Kyoto Prefectural University of Medicine between 1997 and 2019 and at the Kyoto Chubu Medical Center between 2009 and 2019.RESULTS:
Fifteen of 38 patients (39.5%) with RGC were positive for LVI. Patients with LVI had a significantly poorer prognosis for both overall survival ([OS] P = 0.006) and recurrence-free survival ([RFS] P = 0.001) than those without LVI. Multivariate analyses using the Cox proportional hazards model revealed LVI as an independent prognostic factor affecting OS (P = 0.024; hazard ratio 8.27, 95% confidence interval1.285-161.6) and RFS (P = 0.013; hazard ratio 8.98, 95% confidence interval1.513-171.2).CONCLUSIONS:
LVI is a prognostic factor for patients with T1N0-3 or T2-3N0 RGC. Evaluating LVI may be useful for determining treatment strategies for RGC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
Limite:
Humans
Idioma:
En
Revista:
World J Surg Oncol
/
World j. surg. oncol. (Online)
/
World journal of surgical oncology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão