Expression and function of cytokine interleukin-22 gene in the tumor microenvironment of triple negative breast cancer.
Cytokine
; 179: 156590, 2024 07.
Article
em En
| MEDLINE
| ID: mdl-38581864
ABSTRACT
BACKGROUND:
The tumor microenvironment (TME) and interleukin-22 (IL-22) in cytokines have recently attracted much attention due to their potential impact on tumor biology. However, the role of IL-22 in triple negative breast cancer (TNBC) TME is still poorly understood. This article investigated the gene expression and function of IL-22 in TNBC TME.METHODS:
Tumor samples from TNBC patients were collected, and adjacent noncancerous tissues were used as controls. A functional test was performed to evaluate the impact of IL-22 for TNBC cells, including proliferation, migration, and apoptosis.RESULTS:
IL-22 gene expression in TNBC tumor samples was markedly higher relative to adjacent non-cancerous tissues (P < 0.05). In addition, it was also observed that IL-22facilitated proliferation and migration of TNBC cells, and inhibit apoptosis. This article reveals the role of IL-22 in the TME of TNBC. The up-regulation of IL-22 gene expression in TNBC tumors and its promoting effect on cancer cell invasiveness highlight its potential as a therapeutic target in TNBC treatment strategies.CONCLUSION:
The findings suggested that targeting IL-22 and its related pathways can offer new insights for developing effective therapies for TNBC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Movimento Celular
/
Interleucinas
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Apoptose
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Proliferação de Células
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Microambiente Tumoral
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Neoplasias de Mama Triplo Negativas
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Interleucina 22
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Cytokine
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China