Yeast Prion Protein Sup35 Initiates &#945;-Synuclein Pathology in Parkinson's Disease.

Wang, Youcui; Li, Hui; Song, Ning; Xie, Junxia

Yeast Prion Protein Sup35 Initiates α-Synuclein Pathology in Parkinson's Disease.

Wang, Youcui; Li, Hui; Song, Ning; Xie, Junxia.

Afiliação

Wang Y; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
Li H; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
Song N; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
Xie J; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.

Mov Disord ; 39(5): 766-767, 2024 May.

Article em En | MEDLINE | ID: mdl-38627965

ABSTRACT

ABSTRACT

Sinus infection of Saccharomyces cerevisiae accelerates the aggregation of α-synuclein (α-syn) in A53T mice, which was caused by prion protein Sup35. Sup35 promotes α-syn aggregation in vitro and in vivo and leads to Parkinson's disease (PD)-like motor impairment in wildtype mice, suggesting that the yeast Sup35 triggers α-syn pathology in PD.

Assuntos

Doença de Parkinson; Fatores de Terminação de Peptídeos; Proteínas de Saccharomyces cerevisiae; alfa-Sinucleína; Animais; Humanos; Camundongos; alfa-Sinucleína/metabolismo; alfa-Sinucleína/genética; Modelos Animais de Doenças; Camundongos Transgênicos; Doença de Parkinson/metabolismo; Doença de Parkinson/patologia; Fatores de Terminação de Peptídeos/metabolismo; Fatores de Terminação de Peptídeos/genética; Príons/metabolismo; Príons/genética; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fatores de Terminação de Peptídeos / Proteínas de Saccharomyces cerevisiae / Alfa-Sinucleína Limite: Animals / Humans Idioma: En Revista: Mov Disord Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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