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Anti-inflammatory monomeric sorbicillinoids from the marine-fish-derived fungus Trichoderma sp. G13.
Zhang, Yuhan; Zhang, Yi; Li, Gang; Dong, Kemin; Wang, Jialing; Xiao, Shengjia; Lou, Hongxiang; Peng, Xiaoping.
Afiliação
  • Zhang Y; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China; Drug Supply Department, Qingdao West Coast New Area Central Hospital, Shandong 266555, People's Republic of China.
  • Zhang Y; Education and Science Office, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China.
  • Li G; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China.
  • Dong K; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China.
  • Wang J; Drug Supply Department, Qingdao West Coast New Area Central Hospital, Shandong 266555, People's Republic of China.
  • Xiao S; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China.
  • Lou H; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China; Key Laboratory of Chemical Biology of Ministry of Education, Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong
  • Peng X; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China. Electronic address: pengxiaoping@qdu.edu.cn.
Fitoterapia ; 175: 105963, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38631598
ABSTRACT
Four new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 14 to 20 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichoderma / Anti-Inflamatórios Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichoderma / Anti-Inflamatórios Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2024 Tipo de documento: Article