Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases.
Front Mol Neurosci
; 17: 1379726, 2024.
Article
em En
| MEDLINE
| ID: mdl-38638604
ABSTRACT
Netrin-1 was initially discovered as a neuronal growth cue for axonal guidance, and its functions have later been identified in inflammation, tumorigenesis, neurodegeneration, and other disorders. We have recently found its alterations in the brains with Alzheimer's disease, which might provide important clues to the mechanisms of some unique pathologies. To provide better understanding of this promising molecule, we here summarize research progresses in genetics, pathology, biochemistry, cell biology and other studies of Netrin-1 about its mechanistic roles and biomarker potentials with an emphasis on clinical neurodegenerative disorders in order to expand understanding of this promising molecular player in human diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Mol Neurosci
/
Frontiers in molecular neuroscience
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China