Harnessing the power of IFN for therapeutic approaches to COVID-19.
J Virol
; 98(5): e0120423, 2024 May 14.
Article
em En
| MEDLINE
| ID: mdl-38651899
ABSTRACT
Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Interferons
/
SARS-CoV-2
/
COVID-19
/
Tratamento Farmacológico da COVID-19
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos