[Adverse events in biologics for severe asthma]. / Effets indésirables des biothérapies de l'asthme sévère.
Rev Mal Respir
; 41(5): 372-381, 2024 May.
Article
em Fr
| MEDLINE
| ID: mdl-38653607
ABSTRACT
INTRODUCTION:
Asthma is a pathology that remains severe and is inadequately controlled in 4% of patients. Identification of multiple pathophysiological mechanisms has led to the development of biomedicines, of which there are currently five available in France, with a safety profile that appears favorable but remains uncertain due to a lack of real-life experience with these new molecules. STATE OF KNOWLEDGE Although relatively benign, the adverse effects of biologics are diverse. Headache, joint pain, skin reactions at the injection site, fever and asthenia are commonly observed during the different treatments. Ophthalmological complications seem restricted to dupilumab, with numerous cases of keratitis and conjunctivitis in patients with atopic dermatitis. Several respiratory complications have also been observed, essentially consisting in pharyngitis and other upper respiratory infections. Hypereosinophilia may occur, mainly with dupilumab, requiring investigation of systemic repercussions or vasculitis. Allergic reactions are uncommon but require careful monitoring during initial injections.CONCLUSION:
Biologics for severe asthma are recent drugs with a favorable safety profile, but with little real-life experience, justifying increased vigilance by prescribing physicians.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Produtos Biológicos
/
Antiasmáticos
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
Fr
Revista:
Rev Mal Respir
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França