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Synthetic cathinones in drug-facilitated sexual assault: A case report involving the novel generation substituted cathinone N-ethylpentedrone and a review of the literature.
Drevin, Guillaume; Gaulier, Jean-Michel; Hakim, Florian; Gish, Alexandr; Férec, Séverine; Renard, Laura; Malbranque, Stéphane; Briet, Marie; Abbara, Chadi.
Afiliação
  • Drevin G; Service de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, Angers, France. Electronic address: Guillaume.Drevin@chu-angers.fr.
  • Gaulier JM; CHU Lille, Unité Fonctionnelle de Toxicologie, Lille 59000, France; Univ. Lille, URL 4483, IMPECS, IMPact de l'Environnement Chimique sur la Santé humaine, Lille, France.
  • Hakim F; CHU Lille, Unité Fonctionnelle de Toxicologie, Lille 59000, France; Univ. Lille, URL 4483, IMPECS, IMPact de l'Environnement Chimique sur la Santé humaine, Lille, France.
  • Gish A; CHU Lille, Unité Fonctionnelle de Toxicologie, Lille 59000, France; Univ. Lille, URL 4483, IMPECS, IMPact de l'Environnement Chimique sur la Santé humaine, Lille, France.
  • Férec S; Service de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, Angers, France.
  • Renard L; Institut de Médecine légale, Centre Hospitalo-Universitaire d'Angers, Angers, France.
  • Malbranque S; Institut de Médecine légale, Centre Hospitalo-Universitaire d'Angers, Angers, France.
  • Briet M; Service de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, Angers, France; Université d'Angers, Angers, France; Laboratoire MitoVasc, Team Carme, SFR ICAT, UMR CNRS 6015 INSERM 1083, Angers, France.
  • Abbara C; Service de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, Angers, France.
Forensic Sci Int ; 359: 112030, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38657324
ABSTRACT
The use of 3,4-methylenedioxymethamphetamine (MDMA) in drug-facilitated sexual assault (DFSA) is not uncommon. Indeed, the effects associated with the use of this substance may lead to disinhibition. Several synthetic cathinones, such as mephedrone or methylone, also possess marked entactogenic properties. This manuscript aims to (i) report a DFSA case involving a novel cathinone derivative, namely N-ethyl-pentedrone (NEPD) and (ii) review previously reported DFSA cases involving synthetic cathinones. Using liquid chromatography-high-resolution mass spectrometry (LC-HRMS), NEPD was detected in both plasma and urine collected from a 36-year-old male who had been victim of DFSA. Furthermore, an exhaustive, non-period-specific English-language literature search was performed using several different electronic databases to identify DFSA cases involving synthetic cathinones. Overall, five synthetic cathinones have been associated with DFSAmethylenedioxypyrovalerone, 4-methylethcathinone, α -pyrrolidinopentiophenone, mephedrone, α -pyrrolidinohexiophenone, and methylone, which appears to be the most frequently reported. Methylone is the ß-keto analog of MDMA, with which it shares substantial pharmacological similarities. Indeed, the pharmacological effects of methylone are similar to those associated with MDMA. By contrast, little is known regarding NEPD's pharmacological effects in humans. Based on subjective reports, NEPD can produce both positive and negative effects in human. Unlike what is reported in the case of methylone or mephedrone, only a small minority of NEPD users report slightly entactogenics effects. Such properties theoretically make NEPD more suitable for use in a chemsex context than in DFSA context; even though, the boundary between these two specific forms of sexualized drug use can sometimes appear tenuous.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Alcaloides Limite: Adult / Humans / Male Idioma: En Revista: Forensic Sci Int Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Alcaloides Limite: Adult / Humans / Male Idioma: En Revista: Forensic Sci Int Ano de publicação: 2024 Tipo de documento: Article
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