Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384.
J Antibiot (Tokyo)
; 77(7): 471-474, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38664572
ABSTRACT
Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 µM, respectively), and IgE-mediated ß-hexosaminidase release in RBL-2H3 cells with IC50 values of 42, 79, and 19 µM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Espectroscopia de Ressonância Magnética
/
Testes de Sensibilidade Microbiana
/
Micrococcus luteus
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão