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Sex-Related Differences in Dispensation of Rheumatic Medications in Older Patients With Inflammatory Arthritis: A Population-Based Study.
Tarannum, Sanjana; Widdifield, Jessica; Wu, C Fangyun; Johnson, Sindhu R; Rochon, Paula; Eder, Lihi.
Afiliação
  • Tarannum S; S. Tarannum, MBBS, MSc, Department of Medicine, Bangladesh Specialized Hospital Ltd, Dhaka, Bangladesh.
  • Widdifield J; J. Widdifield, PhD, Sunnybrook Research Institute, and University of Toronto, Toronto, Ontario, Canada.
  • Wu CF; C.F. Wu, MSc, ICES, Toronto, Ontario, Canada.
  • Johnson SR; S.R. Johnson, MD, PhD, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
  • Rochon P; P. Rochon, MD, MPH, Women's Age Lab, and Women's College Research Institute, and Women's College Hospital, ICES, and Department of Medicine, Division of Geriatric Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Eder L; L. Eder, MD, PhD; Division of Rheumatology, Women's College Hospital, and Department of Medicine; University of Toronto, Toronto, Ontario, Canada. lihi.eder@wchospital.ca.
J Rheumatol ; 51(7): 703-707, 2024 Jul 01.
Article em En | MEDLINE | ID: mdl-38692668
ABSTRACT

OBJECTIVE:

The aim of our study was to compare dispensation of rheumatic medications between older male and female patients with early rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

METHODS:

This retrospective cohort study was performed using health administrative data from Ontario, Canada (years 2010-2017), on patients with incident RA and PsA, who were aged ≥ 66 years at the time of diagnosis. Yearly dispensation of rheumatic drugs was compared between older male and female patients for 3 years after diagnosis using multivariable regression models, after adjusting for confounders. The groups of drugs included in the analysis were disease-modifying antirheumatic drugs (DMARDs) classified as conventional synthetic DMARDs (csDMARDs) and advanced therapy (biologic DMARDs and targeted synthetic DMARDs), nonsteroidal antiinflammatory drugs (NSAIDs), opioids, and oral corticosteroids. Results were reported as odds ratios (ORs) with 95% CIs.

RESULTS:

We analyzed 13,613 patients (64% female) with RA and 1116 patients (57% female) with PsA. Female patients with RA were more likely to receive opioids (OR 1.39, 95% CI 1.22-1.58 to OR 1.51, 95% CI 1.32-1.72) and NSAIDs (OR 1.14, 95% CI 1.04-1.25 to OR 1.16, 95% CI 1.04-1.30). Dispensation of DMARDs showed no sex difference in either group. Subgroup analyses showed more intense use of advanced therapy in the RA cohort and of csDMARDs in the PsA cohort when patient and physician sex was concordant.

CONCLUSION:

This study did not identify any sex difference in the use of DMARDs among older patients with RA and PsA. The reasons for the higher use of opioids and NSAIDs among female patients with RA warrant further research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Artrite Psoriásica / Anti-Inflamatórios não Esteroides / Antirreumáticos Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bangladesh

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Artrite Psoriásica / Anti-Inflamatórios não Esteroides / Antirreumáticos Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bangladesh
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