Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets.
Cell Mol Gastroenterol Hepatol
; 18(3): 101352, 2024.
Article
em En
| MEDLINE
| ID: mdl-38697358
ABSTRACT
Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients with chronic alcohol-associated liver disease (ALD). Patients with severe AH have high short-term mortality and lack effective pharmacologic therapies. Inflammation is believed to be one of the key factors promoting AH progression and has been actively investigated as therapeutic targets over the last several decades, but no effective inflammatory targets have been identified so far. In this review, we discuss how inflammatory cells and the inflammatory mediators produced by these cells contribute to the development and progression of AH, with focus on neutrophils and macrophages. The crosstalk between inflammatory cells and liver nonparenchymal cells in the pathogenesis of AH is elaborated. We also deliberate the application of recent cutting-edge technologies in characterizing liver inflammation in AH. Finally, the potential therapeutic targets of inflammatory mediators for AH are briefly summarized.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatite Alcoólica
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Gastroenterol Hepatol
Ano de publicação:
2024
Tipo de documento:
Article