Renal thrombotic microangiopathy is associated with poor renal survival in children with immunoglobulin A nephropathy.
Nephrology (Carlton)
; 29(9): 579-587, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38716715
ABSTRACT
AIM:
The aim of this study was to examine the clinical and pathological characteristics as well as the prognosis of immunoglobulin A nephropathy (IgAN) accompanied by renal thrombotic microangiopathy (rTMA) in paediatric patients.METHODS:
After balancing epidemiological characteristics and pathological types between groups, 427 patients (rTMA group 23, non-rTMA group 46) were included. The clinical and pathological features, prognosis and clinical risk factors of the two groups were analysed.RESULTS:
IgAN-rTMA children showed more severe clinical and pathological manifestations. The findings from the logistic regression analysis indicated that hypercellularity 1 (E1) (HR 0.805, 95% CI 0.763 ~ 1.452, P = .016), endocapillary proliferation (HR 1.214, 95% CI 0.093 ~ 4.815, P = .025) and C3 staining (HR 7.554, 95% CI 2.563 ~ 15.729, P = .037) were the risk factors for rTMA in children with IgAN. The renal survival in rTMA group was lower than non-rTMA group (χ2 = 18.467, P = .000). Cox regression analysis showed that E1 (HR 7.441, 95% CI 1.095 ~ 10.768, P = .037), C3 disposition (HR 3.414, 95% CI 0.834 ~ 11.578, P = .027) and rTMA (HR 8.918, 95% CI 1.032 ~ 16.754, P = .041) were identified as independent risk factors for the development of end-stage renal disease (ESRD).CONCLUSION:
The presence of rTMA had a significant impact on the severity and prognosis of IgAN. And rTMA has been identified as an independent risk factor for the development of renal failure in children diagnosed with IgAN.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microangiopatias Trombóticas
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Glomerulonefrite por IGA
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Nephrology (Carlton)
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China