Update on human herpesvirus 7 pathogenesis and clinical aspects as a roadmap for future research.
J Virol
; 98(6): e0043724, 2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38717112
ABSTRACT
Human herpesvirus 7 (HHV-7) is a common virus that is associated with various human diseases including febrile syndromes, dermatological lesions, neurological defects, and transplant complications. Still, HHV-7 remains one of the least studied members of all human betaherpesviruses. In addition, HHV-7-related research is mostly confined to case reports, while in vitro or in vivo studies unraveling basic virology, transmission mechanisms, and viral pathogenesis are sparse. Here, we discuss HHV-7-related literature linking clinical syndromes to the viral life cycle, epidemiology, and viral immunopathogenesis. Based on our review, we propose a hypothetical model of HHV-7 pathogenesis inside its host. Furthermore, we identify important knowledge gaps and recommendations for future research to better understand HHV-7 diseases and improve therapeutic interventions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 7
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Infecções por Roseolovirus
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Pesquisa Biomédica
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Bélgica