Inhibitory nitric oxide production and cytotoxic activities of phenolic compounds from Gnetum montanum Markgr.
Nat Prod Res
; : 1-6, 2024 May 10.
Article
em En
| MEDLINE
| ID: mdl-38728614
ABSTRACT
One new compound, styrene dimer-type listeanol-4-O-α-Ê-rhamnopyranosyl-(1â4)-ß-á´
-glucopyranoside (1), and four known compounds namely listeanol (2), isorhapotigenin (3), genetifolin E (4), gnetifolin K (5) were isolated from the methanolic extract from the aerial part of the Gnetum montanum Markgr. in Viet Nam. Their chemical structures were determined by modern spectroscopic methods (NMR and HR-ESI-MS) and comparison with those of published data. These compounds were evaluated for their anti-inflammatory and cytotoxic activities. Among them, compound 3 exhibited the NO inhibitory production on the RAW264.7 cell line, and inhibited the HepG2 cell line with respective IC50 values of 79.88 ± 5.51 (µg/mL) (L-NMMA 7.90 ± 0.63 µg/mL), and 63.48 ± 3.63 (µg/mL) (Ellipticine 0.40 ± 0.01 µg/mL).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Nat Prod Res
/
Nat. prod. res. (Online)
/
Natural product research (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Vietnã