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Photosynthetic Bacteria-Hitchhiking 2D iMXene-mRNA Vaccine to Enable Photo-Immunogene Cancer Therapy.
Zhang, Shen; Yu, Jifeng; Liu, Yunyun; Xiong, Bing; Fang, Yan; Zhu, Yuli; Li, Shaoyue; Sun, Liping; Zhou, Boyang; Sun, Yikang; Wang, Lifan; Yue, Wenwen; Yin, Haohao; Xu, Huixiong.
Afiliação
  • Zhang S; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
  • Yu J; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
  • Liu Y; Department of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, School of Medicine, Tongji University. Shanghai 200072, P. R. China.
  • Xiong B; Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Nanjing Medical University, Shanghai, 200072, P. R. China.
  • Fang Y; Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, P. R. China.
  • Zhu Y; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
  • Li S; Department of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, School of Medicine, Tongji University. Shanghai 200072, P. R. China.
  • Sun L; Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Nanjing Medical University, Shanghai, 200072, P. R. China.
  • Zhou B; Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, P. R. China.
  • Sun Y; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
  • Wang L; Department of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, School of Medicine, Tongji University. Shanghai 200072, P. R. China.
  • Yue W; Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Nanjing Medical University, Shanghai, 200072, P. R. China.
  • Yin H; Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, P. R. China.
  • Xu H; Department of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, School of Medicine, Tongji University. Shanghai 200072, P. R. China.
Adv Sci (Weinh) ; 11(28): e2307225, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38742454
ABSTRACT
Therapeutic mRNA vaccines have become powerful therapeutic tools for severe diseases, including infectious diseases and malignant neoplasms. mRNA vaccines encoding tumor-associated antigens provide unprecedented hope for many immunotherapies that have hit the bottleneck. However, the application of mRNA vaccines is limited because of biological instability, innate immunogenicity, and ineffective delivery in vivo. This study aims to construct a novel mRNA vaccine delivery nanosystem to successfully co-deliver a tumor-associated antigen (TAA) encoded by the Wilms' tumor 1 (WT1) mRNA. In this system, named PSB@Nb1.33C/mRNA, photosynthetic bacteria (PSB) efficiently delivers the iMXene-WT1 mRNA to the core tumor region using photo-driven and hypoxia-driven properties. The excellent photothermal therapeutic (PTT) properties of PSB and 2D iMxene (Nb1.33C) trigger tumor immunogenic cell death, which boosts the release of the WT1 mRNA. The released WT1 mRNA is translated, presenting the TAA and amplifying immune effect in vivo. The designed therapeutic strategy demonstrates an excellent ability to inhibit distant tumors and counteract postsurgical lung metastasis. Thus, this study provides an innovative and effective paradigm for tumor immunotherapy, i.e., photo-immunogene cancer therapy, and establishes an efficient delivery platform for mRNA vaccines, thereby opening a new path for the wide application of mRNA vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Anticâncer / Imunoterapia Limite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) / Advanced science (Weinheim) Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Anticâncer / Imunoterapia Limite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) / Advanced science (Weinheim) Ano de publicação: 2024 Tipo de documento: Article