European survey showed wide variations in diagnostic procedures and management strategies for metabolic bone disease of prematurity in 22 countries.
Acta Paediatr
; 113(8): 1908-1915, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38752585
ABSTRACT
AIM:
The aim of this study was to evaluate the clinical relevance, diagnostic procedures and treatment strategies for metabolic bone disease in preterm infants across Europe.METHODS:
An e-survey was distributed by email to 545 neonatal units in 38 European countries between July and October 2021. The protocol was based on the Checklist for Reporting Results of Internet E-Surveys.RESULTS:
In total, 76 neonatal units (14%) from 22 European countries (58%) completed the e-survey. In the 12 months prior to the survey, 29% of 76 units reported at least one symptomatic case of fracture associated with metabolic bone disease of prematurity, and 18% of 76 units reported at least one case of craniofacial deformity. Most centres followed local guidelines for diagnosis (77% of 73 units) and treatment (63% of 72 units). Alkaline phosphatase was the blood marker most used for treatment indication (81% of 72 units), and phosphate supplementation was the treatment most used (82% of 71 units).CONCLUSION:
Metabolic bone disease of prematurity remains clinically relevant. Wide variations in diagnostic procedures and management strategies were observed in European neonatal units. Evidence-based consensus guidelines appear urgently needed to reduce the number of symptomatic cases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Ósseas Metabólicas
/
Recém-Nascido Prematuro
/
Doenças do Prematuro
Limite:
Humans
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Acta Paediatr
/
Acta paediatr. scand
/
Acta paediatrica scandinavica
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha