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Metabolic characteristics of evodiamine were associated with its hepatotoxicity via PPAR/PI3K/AKT/NF-кB/tight junction pathway-mediated apoptosis in zebrafish.
Fan, Qiqi; Liang, Ruiqiang; Chen, Meilin; Li, Zhiqi; Tao, Xiaoyu; Ren, Hongmin; Sheng, Yuhan; Li, Jiaqi; Lin, Ruichao; Zhao, Chongjun; She, Gaimei.
Afiliação
  • Fan Q; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Liang R; National Institutes for Food and Drug Control, Beijing 100050, China.
  • Chen M; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Li Z; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Tao X; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Ren H; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Sheng Y; Beijing University of Chinese Medicine, Beijing 100102,China.
  • Li J; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China.
  • Lin R; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China. Electronic address: linrch307@sina.com.
  • Zhao C; Beijing University of Chinese Medicine, Beijing 100102,China; Beijing Key laboratory for Quality Evaluation of Chinese Materia Medica, Beijing 100102, China. Electronic address: 1014256537@qq.com.
  • She G; Beijing University of Chinese Medicine, Beijing 100102,China. Electronic address: shegaimei@126.com.
Ecotoxicol Environ Saf ; 279: 116448, 2024 Jul 01.
Article em En | MEDLINE | ID: mdl-38754199
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Peixe-Zebra / NF-kappa B / Apoptose / Fosfatidilinositol 3-Quinases / Evodia / Proteínas Proto-Oncogênicas c-akt Limite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Peixe-Zebra / NF-kappa B / Apoptose / Fosfatidilinositol 3-Quinases / Evodia / Proteínas Proto-Oncogênicas c-akt Limite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China