IL-33 in patients with periodontitis and chronic obstructive pulmonary disease.
Hum Immunol
; 85(4): 110811, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38755030
ABSTRACT
OBJECTIVE:
A link between periodontitis and chronic obstructive pulmonary disease (COPD) has been identified, and interleukin-33 (IL-33) may play an important role in the common inflammatory mechanisms of these diseases. This study analyzed the associations of the serum IL-33 level with the occurrence and severity of periodontitis and COPD.METHODS:
A total of 161 participants were divided into four groups healthy volunteers, periodontitis patients, COPD patients, and patients with both COPD and periodontitis. Associations between serum IL-33 levels were measured by enzyme-linked immunosorbent assay, and clinical factors as well as the risks and severity of periodontitis and COPD were analyzed.RESULTS:
Serum IL-33 levels were lower in all patient groups than in healthy controls. A trend toward lower IL-33 levels was observed among patients with both diseases compared with patients with either disease alone. The serum IL-33 level was also inversely associated with the severity of periodontitis and COPD. The serum IL-33 level was negatively associated with risks of periodontitis and COPD, indicating that IL-33 is likely involved in the pathophysiologic mechanism of the relationship between COPD and periodontitis.CONCLUSION:
This study advances our understanding of the association between COPD and periodontitis and provides new bases for COPD prevention and treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Doença Pulmonar Obstrutiva Crônica
/
Interleucina-33
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hum Immunol
/
Hum. immunol
/
Human immunology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China