Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread.
Best Pract Res Clin Obstet Gynaecol
; 95: 102500, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38772765
ABSTRACT
Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
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Fertilização in vitro
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Hormônio Liberador de Gonadotropina
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Acetato de Medroxiprogesterona
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Inibidores da Aromatase
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Endometriose
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Infertilidade Feminina
Limite:
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Bailliere's best practice & research. Clinical obstetrics & gynaecology
/
Best Pract Res Clin Obstet Gynaecol
/
Best pract. res., Clin. obstet. gynaecol
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2024
Tipo de documento:
Article