Plasma proenkephalin and neutrophil gelatinase-associated lipocalin predict mortality in ICU patients with acute kidney injury.
BMC Nephrol
; 25(1): 181, 2024 May 22.
Article
em En
| MEDLINE
| ID: mdl-38778257
ABSTRACT
BACKGROUND:
Acute kidney injury (AKI) is a common complication in patients admitted to intensive care unit (ICU) and mortality rates for this condition are high. To reduce the high incidence of short-term mortality, reliable prognostic indicators are required to facilitate early diagnosis and treatment of AKI. We assessed the ability of plasma proenkephalin (pPENK) and plasma neutrophil gelatinase-associated lipocalin (pNGAL) to predict 28-day mortality in AKI patients in intensive care.METHODS:
This prospective study, carried out between January 2019 and December 2019, comprised 150 patients (100 male) diagnosed with AKI after excluding 20 patients discharged within 24 h and those with missing hospitalization data. Blood samples were collected to determine admission p-PENK and p-NGAL levels. The study outcome was 28day mortality.RESULTS:
The mean patient age was 68 years (female, 33%). The average PPENK and pNGAL levels were 0.24 ng/µL and 223.70 ng/mL, respectively. PPENK levels >0.36 ng/µL and pNGAL levels >230.30 ng/mL were used as critical values to reliably indicate 28day mortality for patients with AKI (adjusted hazard ratios 0.785 [95% confidence interval 0.706-0.865, P<0.001] and 0.700 [95% confidence interval 0.611-0.789, P<0.001], respectively). This association was significant for mortality in patients in intensive care with AKI. Baseline p-PENK (0.36 ng/µL) and p-NGAL (230.30 ng/mL) levels and their respective cut-off values showed clinical value in predicting 28-day mortality.CONCLUSION:
Serum PENK and NGAL levels, when used in conjunction, improved the accuracy of predicting 28-day mortality in patients with AKI while retaining sensitivity and specificity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalinas
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Biomarcadores
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Injúria Renal Aguda
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Lipocalina-2
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Unidades de Terapia Intensiva
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMC Nephrol
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China